When is a Clone Not a Clone

sonogram image of twin in utero
Twin #2 by Jim Moran, Flickr Creative Commons

Bees do it. Lizards and snakes do it. Turkeys and Komodo Dragons can do it. Have babies without daddies, that is. It’s called Parthenogenesis. Parthenogenesis a form of asexual reproduction in which growth of the embryo occurs without fertilization. Growth of the embryo begins due to a change in temperature, a mechanical action, or a chemical action. The term applies only to animals. (Botanical asexual reproduction is called something else.) And since the offspring are clones of the mother, they are usually female.

This phenomenon was first observed in aphids and recorded by Charles Bonnet in the 18th century.

In 1899, Jacques Loeb reported artificial parthenogenesis in sea urchins. Gregory Pincus used temperature and chemicals to induce embryonic development in rabbit eggs in 1936. Today, some sources say about 70 vertebrates can reproduce this way and, if you include all organisms that number will top 2000 species.

Some species are obligatory parthenogenic, in other words, they cannot reproduce sexually at all. Other species are facultatively parthenogenic, meaning they have the ability to switch between sexual and parthenogenic reproduction.

There have been no known natural parthenogenic offspring in mammals. There are a number of different theories as to why that is, but it was reported in 2004 that one laboratory created parthenogenic mice. It was a lengthy, complicated, and inefficient process.

Not a Clone?

Cloning is different from parthenogenesis. According to The American Heritage Medical Dictionary cloning is “the transplantation of a nucleus from a somatic cell (a body cell, not a gamete) into an ovum, which then develops into an embryo.” Mosby’s Medical Dictionary goes a little farther in its definition, “a procedure for producing multiple copies of genetically identical organisms or of cells or of individual genes. . . .”

The offspring in cloning can be not identical to the parent organism if either somatic cell or the ovum are not from the parent organism.

In parthenogenesis the process of fertilization does not happen. Thus the offspring is identical since no new DNA is required.

Then there are the different types of cloning: recombinant DNA, Reproductive Cloning, and Therapeutic Cloning. Each could be topics of their own, so I won’t get into the details here. If you’re curious, I’ve listed my online resources below.

Do You Know a Clone?

Since there has been no confirmed, recorded human clones born, many of you will answer this question in the negative. Or perhaps you will remember Dolly the Sheep (1996-2003), the first cloned mammal. Yet, I’ll bet you know at least one set of identical twins. Identical twins have identical DNA, they come from a single cell. And it appears that nearly every species on Earth can bear twins.

Twin Parade
Twin Parade @Just for laughs festival, 2008, Montreal flickr creative commons

Will the True Clone Please Stand?

So which process creates a true clone? Is it okay to take the parthenogenic or cloning process just so far as to make stem cells and not allow the cells to develop into an organism? Why do we need this research, you ask?

Stem cell research has already shown us that it has terrific potential to cure deadly diseases such as cancer and diabetes. It’s just a tantalizing glimpse of what may be possible. Think of the many millions of people who may be helped by this process.

And what about invitro fertilization? Most of us accept that this is one way for couples unable to conceive naturally to be able to have children. Is this cloning? What if, only one partner was able to contribute the cells to create the offspring due to genetic or other disease? 

If we could repopulate endangered species through cloning, would that be an acceptable use of the process?

If we outlaw cloning, do we outlaw the cloning and the parthenogenesis that nature affords us? Would you get rid of those cute identical twins everyone likes to oooh and ahh at?

What’s in a Word?

Does the difference in semantics affect the ethics of this situation? For many people the answer is no. And I respect their concerns. There are reasons to be concerned. As with most scientific discoveries there is the potential for both an immense amount of good and terrible wrongs.

Not to make light of anyone’s particular beliefs, there is no easy answer.

As a science fiction author and a nurse, I find this topic is a gold mine of information and emotional reactions. I’m having fun using parthenogenesis as a springboard to explore a little of the controversies involved.

 Do you read fiction that takes on controversial issues? Has a book or article about such a controversial issue ever changed your mind?

Your responses to this topic are important to me. In fact, some of your answers may fuel development in my novel. I only ask that you respect others who may reply with differing opinions. Thank you so much.

 

If you’d like to learn more, here are some of my online resources:

10 thoughts on “When is a Clone Not a Clone

  1. I like fiction that makes me think; I loathe fiction that tries to tell me how to think. Unfortunately, much fiction dealing with controversial topics tends ro lean toward the latter. But if the author can trandscend that, I’m in. Fascinating topic!

  2. What a fascinating topic, Lynette. I love the pic of the ultrasound. At first I thought you were going to announce you have a grandchild on the way. I have two more grandbabies due the end of May, beginning of June, so that’s where my mind is these days! No, they’re not twins. One’s my dauther’s and the other my son’s. Isn’t that something that my grandbabies could be born within the same week?

    The whole cloning issue has so many angles to it, plenty of room for abuse. I love the idea for fiction. The first date I went on with my husband was to see the Woody Allen movie “Sleeper.” That was pretty funny. And then Arnold Schwarzenegger’s movie “The Sixth Day” is one of my favorites. Kinda violent, but I loved it!

    1. Congratulations, Lynn! That is something. Might be a bit stressful on grandma trying to be in two places at once, but it’s a good stress. 🙂

      “Sleeper” and “The 6th Day?” What a combo! LOL. I’m not much of a Woody Allen fan, but I liked “The 6th Day” as well.

      Thanks for sharing, Lynn!

  3. Fascinating post, Lynette, and thought-provoking as well. I love to read fiction that takes science and creates a world with it, if you will, as well as fiction that chooses a philosophical issue as a basis for creating a world.

    I can’t say that I’ve found a lot of that type of fiction that pleases me but in reading any book, I will stay with the story as long as the book is well-written, meaning not only style but the writer understands conflict. I just read “The Dog Stars” (Phil Heller), which is described as a post apocalyptic novel, not a favorite topic of mine but it so well written that I have reconsidered my opinion about post-apocalyptic story lines.If I remember correctly, it is Heller’s first novel.

    I am most fascinated by your discussion of clones and parthenogenesis. It does seem ripe for a good story.

    Karen

    1. Karen, you’re right, it’s difficult to find good novels that make philosophical issues part of the core story. I may have to try Heller’s book. Thanks for the recommendation. And thanks for stopping by!

  4. fascinating post, Lynette. who knew? I have to admit, cloning scares the daylights out of me. I fear that it will create way more problems than it solves. but that’s just the cynic in me. thanks for such good information.

    1. You’ve every right to be concerned. Cloning definitely has potential for some huge issues. It also has huge potential for organ transplant and gene therapies. I can see both sides, but I tend toward the cynic side myself.

    1. Yes, Coleen, that’s another controversy. I know there is research into cloning various organs and creating stem cells, so maybe cloning would resolve the issue of having a child to cure a child. Then again, maybe the cloning would simply reproduce the disease. Sticky issues.

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